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dc.rights.licensehttp://creativecommons.org/licenses/by-nc-sa/3.0/ve/
dc.contributor.authorPáez, Ximena
dc.contributor.authorHernández R., Luis F.
dc.date.accessioned2015-02-05T20:31:34Z
dc.date.available2015-02-05T20:31:34Z
dc.date.issued2001
dc.identifier.urihttp://www.saber.ula.ve/handle/123456789/39735
dc.descriptionArtículo publicado en: BIOPHARMACEUTICS & DRUG DISPOSITION Biopharm. Drug Dispos.2001; 22: 273–289.es_VE
dc.description.abstractCapillary electrophoresis (CE) is a high-efficiency analytical technique that has had a great impact as a tool in biomedical research, clinical and forensic practice in the last ten years. Only in one of the applications, the DNA analysis, it has had an explosive exponential growth in the last few years. This impact is expressed in an enormous amount of CE articles and many reviews. The CE advantages with respect to other analytical techniques: the required very small sample volume, rapid analysis, great resolution power and low costs, have made this technique ideal for the analysis of a numerous endogenous and exogenous substances present in biological fluids. The different modes of CE have been coupled to different detection techniques such as UV-absorbance, electrochemical, mass spectrometry and laser-induced fluorescence detection (LIFD) to detect different nature and molecular size separated analytes. This review focuses mostly on the applications of CE–LIFD, to measure drugs and endogenous neuroactive substances such as amino acids and monoamines, especially in microdialysis samples from experimental animals and humans. CE–LIFD trends are discussed: automated faster analysis with capillary array systems, resolution power improvement, higher detection sensitivity, and CE systems miniaturization for extremely small sample volume, in order to make CE easier and affordable to the lab bench or the clinical bed. Copyright # 2001 John Wiley & Sons, Ltd.es_VE
dc.language.isoenes_VE
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleBiomedical applications of capillary electrophoresis with laser-induced fluorescence detectiones_VE
dc.typeinfo:eu-repo/semantics/article
dc.description.colacion237-289es_VE
dc.description.emailpacap@ula.vees_VE
dc.description.emailhernande@ula.vees_VE
dc.publisher.paisVenezuelaes_VE
dc.subject.facultadFacultad de Medicinaes_VE
dc.subject.institucionUniversidad de Los Andeses_VE
dc.subject.keywordsMicrodialysises_VE
dc.subject.keywordsAmino acidses_VE
dc.subject.keywordsHeuroactive substanceses_VE
dc.subject.keywordsDrug analysises_VE
dc.subject.keywordsBiological fluidses_VE
dc.subject.keywordsBraines_VE
dc.subject.keywordsHumanes_VE
dc.subject.keywordsRates_VE
dc.subject.tipoArtículoses_VE
dc.subject.unidadinvLaboratorio de Fisiología de la Conductaes_VE
dc.type.mediaTextoes_VE


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