The small granular-like fungus cells of H. caps. var. capsulatum are yeast-like in the tissues and have a size of 2-4 µ. Here they are seen with high power in the HE stain and are intracellularly arranged. The other variety of the genus Histoplasma capsulatum is called H.caps.var duboisii which are large yeast cells reaching the size of 15-20 µ. The autochthonous infection of this mycosis occurs only in Central Africa and apparently also by inhalation. The skin and Fig bones are mostly affected. The histological aspect of this variety will be shown in case 50.