Begin  The Authors
 Introduction

Tropical Diseases:

I Leishmaniasis
II Paracoccidioidomycosis
III Blastomycocis
IV Chromoblastomycosis
V Lepra
VI Sporotrichosis
VII Histoplasmosis
VIII Rhinosporidiosis
IX Mycetomas
X Rhinoscleroma
XI Chagasdisease
XII Actinomycosis
XIII Mucormycosis
XIV Amoebiasis
XV Protothecosis
XVI Lobomycosis
XVII Phaeohyphomycosis
XVIII Pruritus actinicus
XIX Bite of snake
XX Coccidioidomycosis

 List of cases

 References
 Contact

VII. Histoplasmosis

Case 48: Histoplasmosis / Epithelioma

Previus Case 47

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Next Case 49

Histoplasmosis

Epithelioma

Click here to see the picture 48-A1
Fig.48-A1
Histoplasmosis

A 61-years old female patient from the State Barinas / Venezuela presents a circular, coin-like ulceration on the left cheek. It was neither painful nor itching and had a diameter of 3 cm. clinically and histologically a Leishmaniasis was assumed. Several intracellular small granules were seen. Later, it could be confirmed that instead of a Leishmaniasis a histoplasmosis existed which could be proved by the Grocott method and by culture.

Click here to see the picture 48-B1
Fig.48-B1
Epithelioma

A 20-years old man from the town of Barinas / Venezuela presented on his left cheek an oval, flat tumor with an ulcer, 2,5 cm. in diameter. The regional lymph nodes were neither enlarged, nor painful. After taking a biopsy the tumor was completely removed by surgery. The further course of the disease is not known.

Click here to see the picture 48-A2
Fig.48-A2
Histoplasmosis

After 3 months of a specific treatment the ulcer on the cheek was completely cured (48-A1), but the patient lost permanently weight and died of a generalized fungus infection with Histoplasma capsulatum var. capsulatum.

Click here to see the picture 48-B2
Fig.48-B2
Epithelioma

A keratotic basal cell epithelioma was dignosed in the biopsy with the formation of horny, partly calcified cysts. The tumor was resected completely.

Click here to see the picture 48-A3
Fig.48-A3
Histoplasmosis

Histologically the biopsy of the ulcer on the cheek (48-A1) showed a granulation tissue with numerous histiocytes, lymphocytes and plasmacells. The few fungus cells were difficult to recognize in the HE stain and with a magnification of 400 x.

Click here to see the picture 48-A4
Fig.48-A4
Histoplasmosis

With the application of the Grocottmethod the small black fungus cells of H. capsulatum var. capsulatum were seen as puntiform elements, partly arranged in clusters. GMS stain; 650 x.


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Facultad de Medicina
Universidad de Los Andes
Merida - Venezuela